Publications
16046
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A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity

Benjamin L. L. Clayton, James D. Kristell, Kevin C. Allan, Erin F. Cohn, Molly Karl, Andrew D. Jerome, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, Alexis Kerr, H. Elizabeth Shick, Jesse A. Sepeda, Eric C. Freundt, Andrew R. Sas, Benjamin M. Segal, Robert H. Miller & Paul J. Tesar

 

Nature Neuroscience

2024

Pervasive environmental chemicals impair oligodendrocyte development

Erin F. Cohn, Benjamin L. L. Clayton, Mayur Madhavan, Kristin A. Lee, Sara Yacoub, Yuriy Fedorov, Marissa A. Scavuzzo, Katie Paul Friedman, Timothy J. Shafer & Paul J. Tesar

 

Nature Neuroscience

2024

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

Benjamin L.L. Clayton, Lilianne Barbar, Maria Sapar, Tomasz Rusielewicz, Kriti Kalpana, Bianca Migliori, The NYSCF Global Stem Cell Array® Team, Daniel Paull, Katie Brenner, Dorota Moroziewicz, Ilana Katz Sand, Patrizia Casaccia, Paul J. Tesar, & Valentina Fossati

 

bioRxiv pre-print

2023

Oligodendrocyte progenitor cell fate and function in development and disease

Benjamin L.L. Clayton & Paul J. Tesar

 

Current Opinion in Cell Biology

2021

Non-canonical targets of HIF1a impair oligodendrocyte progenitor cell function

Allan KC, Hu LR, Scavuzzo MA, Morton AR, Gevorgyan AS, Cohn, E., Clayton BLL, Bederman I, Hung S, Bartels CF, Madhavan M, Tesar PJ.

 

Cell Stem Cell

2021

Disorders of myelin (Chapter 13)

Benjamin L.L. Clayton, Kevin C. Allan, Zachary S. Nevin, Matthew S. Elitt, & Paul J. Tesar

 

Editors: Rubenstein J, Rakic P, Chen B, Kwan KY,

 

Neurodevelopmental Disorders (Book)

2020

Developing therapeutic strategies to promote myelin repair in multiple sclerosis

Baldassari LE, Feng J, Clayton BLL, Oh SH, Sakaie K, Tesar PJ, Wang Y, Cohen JA.

 

Expert Review of Neurotherapeutics

2019

Rapid functional genetics of oligodendrocyte lineage using pluripotent stem cells

Angela M Lager, Olivia G Corradin, Jared M Cregg, Matthew S Elitt, H Elizabeth Shick, Benjamin L L Clayton, Kevin C Allan, Hannah E Olsen, Mayur Madhavan, Paul J Tesar

 

Nature Communications

2018

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

Matthew S Elitt, H Elizabeth Shick, Mayur Madhavan, Kevin C Allan, Benjamin L L Clayton, Chen Weng, Tyler E Miller, Daniel C Factor, Lilianne Barbar, Baraa S Nawash, Zachary S Nevin, Angela M Lager, Yan Li, Fulai Jin, Drew J Adams, Paul J Tesar

 

Stem Cell Reports

2018

Induction of myelinating oligodendrocytes in human cortical spheroids. 

Mayur Madhavan, Zachary S Nevin, H Elizabeth Shick, Eric Garrison, Cheryl Clarkson-Paredes, Molly Karl, Benjamin L L Clayton, Daniel C Factor, Kevin C Allan, Lilianne Barbar, Tanya Jain, Panagiotis Douvaras, Valentina Fossati, Robert H Miller, Paul J Tesar

 

Nature Methods

2018

The Integrated Stress Response in Hypoxia-Induced Diffuse White Matter Injury. 

Benjamin LL Clayton, Aaron Huang, Rejani B Kunjamma, Ani Solanki, Brian Popko

 

Journal of Neuroscience

2017

Neonatal Hypoxia Results in Peripheral Nerve Abnormalities

Benjamin LL Clayton, Aaron Huang, Danuta Dukala, Betty Soliven, Brian Popko

 

American Journal of Pathology

2017

Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L L Clayton, Jared B Vasquez, Carson van Sanford, Robert J Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel, Steven Estus, Gopal Thinakaran

 

Molecular Neurodegeneration

2016

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

Sharon W Way, Joseph R Podojil, Benjamin LL Clayton, Anita Zaremba, Tassie L Collins, Rejani B Kunjamma, Andrew P Robinson, Pedro Brugarolas, Robert H Miller, Stephen D Miller, Brian Popko

 

Nature Communications

2015

IFNy-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

Aya D Pusic, Kae M Pusic, Benjamin LL Clayton, Richard P Kraig

 

Journal of Neuroimmunology

2013

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

Wensheng Lin, Yifeng Lin, Jin Li, Ali G Fenstermaker, Sharon W Way, Benjamin LL Clayton, Stephanie Jamison, Heather P Harding, David Ron, Brian Popko

 

Journal of Neuroscience

2013